What is the difference between Necrosis and Apoptosis?

Last Updated on Sunday, 25 July 2010 07:34 Written by Administrator Sunday, 25 July 2010 07:34

Question by enter name here: What is the difference between Necrosis and Apoptosis?
can some body explain it to me please? i have an assignment on this and i’m not quiet sure what they are.
your help would be really appreciated!!!.

Best answer:

Answer by taffy
apoptosis: a type of cell death in which the cell uses specialized cellular machinery to kill itself; a cell suicide mechanism that enables metazoans to control cell number and eliminate cells that threaten the animal’s survival

necrosis: the localized death of living cells (as from infection or the interruption of blood supply)

Apoptosis :

Physiological or pathological
Single cells
Energy dependent
Cell shrinkage
Membrane integrity maintained
Role for mitochondria and cytochrome C
No leak of lysosomal enzymes
Characteristic nuclear changes
Apoptotic bodies form
DNA cleavage
Activation of specific proteases
Regulatable process
Evolutionarily conserved
Dead cells ingested by neighbouring cells

Necrosis:

Always pathological
Sheets of cells
Energy independent
Cell swelling
Membrane integrity lost
No role for mitochondria
Leak of lysosomal enzymes
Nuclei lost
Do not form
No DNA cleavage
No activation
Not regulated
Not conserved
Dead cells ingested by neutrophils and macrophages

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What is the difference between Necrosis and Apoptosis?